Clinical trial Predictive value of apoptosis, proliferation, HER-2, and topoisomerase IIa for anthracycline chemotherapy in locally advanced breast cancer
نویسندگان
چکیده
G. Arpino, D.R. Ciocca, H. Weiss, D.C. Allred, P. Daguerre, L. Vargas-Roig, M. Leuzzi, F. Gago, R. Elledge, and S. K. Mohsin Baylor College of Medicine, Houston, Texas, USA; Institute of Experimental Medicine and Biology of Cuyo, Mendoza, Argentina; Hospital L. Lagomaggiore, Medical School, University of Cuyo, Mendoza, Argentina Hospital Italiano, Medical School, University of Cuyo, Mendoza, Argentina
منابع مشابه
Polymorphism C3435T of the MDR-1 gene predict response to preoperative chemotherapy in locally advanced breast cancer with Her2/neu expression.
AIM to reveal the role of polymorphism C3435T of MDR-1 gene in the response to preoperative chemotherapy in locally advance breast cancer. METHODS the analytical observational research in nineteen patients diagnosed between January and December 2005 with locally advanced breast cancer treated by preoperative Anthracycline chemotherapy to evaluate its predictive outcome was performed. On all s...
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PURPOSE To assess the value of changes in the expression of topoisomerase IIalpha (TopoII) and the proto-oncogene erbB-2 (HER-2) as predictors of relapse-free survival in women with operable breast cancer treated with anthracycline-based neoadjuvant chemotherapy. PATIENTS AND METHODS Seventy-seven patients with primary breast cancer who had undergone neoadjuvant anthracycline-based chemothera...
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PURPOSE Anthracyclines and taxanes are considered the standard for neoadjuvant chemotherapy of breast cancer, although they are often associated with serious side effects and wide variability of individual response. In this study, we analyzed the value of topoisomerase II alpha (TOP2A) and transducin-like enhancer of split 3 (TLE3) as predictive markers of response to therapy with anthracycline...
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Objective The mortality of patients with locally advanced triple-negative breast cancer (TNBC) is high, and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) is associated with improved prognosis. This retrospective study was designed and powered to investigate the ability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to predict pat...
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تاریخ انتشار 2005